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Deformability screening identifies NUDT5 as a mediator of cellular mechanobiology

2026-07-16

Abstract excerpt

How cells deform, sense, and respond to mechanical cues drives physiological and disease processes ranging from development to cancer metastasis; however, unbiased approaches to identify mechanical mediators are lacking. We screened 1280 compounds to identify modulators of cancer cell deformability using a cellular filtration assay and identified 92 compounds that significantly reduced deformability of ovarian can...

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Literature Corpus work
87cff0b8-2c8c-5b01-a8c0-bf7ce40b7a25
DOI
10.64898/2026.07.15.734864
Open publication

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Deformability screening identifies NUDT5 as a mediator of cellular mechanobiologyDOI 10.64898/2026.07.15.734864
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