Article

Negative Selection Allows DNA Mismatch Repair-Deficient Mouse Fibroblasts <i>In Vitro</i> to Tolerate High Levels of Somatic Mutations

2024-05-07

Abstract excerpt

<h4>Summary</h4> Substantial numbers of somatic mutations have been found to accumulate with age in different human tissues. Clonal cellular amplification of some of these mutations can cause cancer and other diseases. However, it is as yet unclear if and to what extent an increased burden of random mutations can affect cellular function without clonal amplification. We tested this in cell culture, which avoids t...

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Literature Corpus work: 3fce5cd5-e444-5853-b7fe-fad645595f55
DOI: 10.1101/2024.05.04.592535

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Negative Selection Allows DNA Mismatch Repair-Deficient Mouse Fibroblasts <i>In Vitro</i> to Tolerate High Levels of Somatic MutationsDOI 10.1101/2024.05.04.592535Read

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