Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains

1 Mar 2025

Abstract excerpt

Outbreaks of chilblains were reported during the COVID-19 pandemic. Given the essential role of type I interferon (I-IFN) in protective immunity against SARS-CoV-2 and the association of chilblains with inherited type I interferonopathies, we hypothesized that excessive I-IFN responses to SARS-CoV-2 might underlie the occurrence of chilblains in this context. We identified a transient I-IFN signature in chilblain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dermatological and COVID-19 studies
Share to Parvovirus B19 Infection Studies
Share to Streptococcal Infections and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40227192
DOI: 10.1084/jem.20231467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblainsPMID 40227192Read ↗

dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunitySemantic proximity Read ↗

Distinct SARS-CoV-2 sensing pathways in pDCs driving TLR7-antiviral vs. TLR2-immunopathological responses in COVID-19Semantic proximity Read ↗

Severe COVID-19 patients have impaired plasmacytoid dendritic cell-mediated control of SARS-CoV-2Semantic proximity Read ↗

Host Genetics and Antiviral Immune Responses in Adult Patients With Multisystem Inflammatory SyndromeSemantic proximity Read ↗

SARS-CoV-2-associated ssRNAs activate inflammation and immunity via TLR7/8Semantic proximity Read ↗

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection.Semantic proximity Read ↗

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infectionSemantic proximity Read ↗

Immune perturbations induced by SARS-CoV2 in infants vary with disease severity and differ from adults’ responsesSemantic proximity Read ↗

SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4Semantic proximity Read ↗

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19Semantic proximity Read ↗

RIG-I-Like Receptors and Type I Interferonopathies.Semantic proximity Read ↗

Interfering with Interferons: A Critical Mechanism for Critical COVID-19 PneumoniaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.