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Article

Determinants of transcription factor regulatory range.

Nature communications - 18 May 2020

Chen Chen-Hao, Zheng Rongbin, Tokheim Collin, Dong Xin, Fan Jingyu, Wan Changxin, Tang Qin, Brown Myles, Liu Jun S, Meyer Clifford A, Liu X Shirley

Abstract excerpt

Characterization of the genomic distances over which transcription factor (TF) binding influences gene expression is important for inferring target genes from TF chromatin immunoprecipitation followed by sequencing (ChIP-seq) data. Here we systematically examine the relationship between thousands of TF and histone modification ChIP-seq data sets with thousands of gene expression profiles. We develop a model for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32424124
DOI: 10.1038/s41467-020-16106-x
PMCID: PMC7235260

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