Article
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Nature - 13 Jul 2017
Huang Hailiang, Fang Ming, Jostins Luke, Umićević Mirkov Maša, Boucher Gabrielle, Anderson Carl A, Andersen Vibeke, Cleynen Isabelle, Cortes Adrian, Crins François, D'Amato Mauro, Deffontaine Valérie, Dmitrieva Julia, Docampo Elisa, Elansary Mahmoud, Farh Kyle Kai-How, Franke Andre, Gori Ann-Stephan, Goyette Philippe, Halfvarson Jonas, Haritunians Talin, Knight Jo, Lawrance Ian C, Lees Charlie W, Louis Edouard, Mariman Rob, Meuwissen Theo, Mni Myriam, Momozawa Yukihide, Parkes Miles, Spain Sarah L, Théâtre Emilie, Trynka Gosia, Satsangi Jack, van Sommeren Suzanne, Vermeire Severine, Xavier Ramnik J, Weersma Rinse K, Duerr Richard H, Mathew Christopher G, Rioux John D, McGovern Dermot P B, Cho Judy H, Georges Michel, Daly Mark J, Barrett Jeffrey C
Abstract excerpt
Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect millions of people worldwide. Genome-wide association studies have identified 200 inflammatory bowel disease-associated loci, but few have been conclusively resolved to specific functional variants. Here we report fine-mapping of 94 inflammatory bowel disease loci using high-density genotyping in 67,852 individuals. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.