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Article

Systematic analysis of chromatin interactions at disease associated loci links novel candidate genes to inflammatory bowel disease.

Genome biology - 30 Nov 2016

Meddens Claartje A, Harakalova Magdalena, van den Dungen Noortje A M, Foroughi Asl Hassan, Hijma Hemme J, Cuppen Edwin P J G, Björkegren Johan L M, Asselbergs Folkert W, Nieuwenhuis Edward E S, Mokry Michal

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have revealed many susceptibility loci for complex genetic diseases. For most loci, the causal genes have not been identified. Currently, the identification of candidate genes is predominantly based on genes that localize close to or within identified loci. We have recently shown that 92 of the 163 inflammatory bowel disease (IBD)-loci co-localize with non-coding...

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Identifiers

PMID: 27903283
DOI: 10.1186/s13059-016-1100-3
PMCID: PMC5131449

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