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Article

Molecular classification of Crohn's disease reveals two clinically relevant subtypes.

Gut - 1 Jan 2018

Weiser Matthew, Simon Jeremy M, Kochar Bharati, Tovar Adelaide, Israel Jennifer W, Robinson Adam, Gipson Gregory R, Schaner Matthew S, Herfarth Hans H, Sartor R Balfour, McGovern Dermot P B, Rahbar Reza, Sadiq Timothy S, Koruda Mark J, Furey Terrence S, Sheikh Shehzad Z

Abstract excerpt

OBJECTIVE: The clinical presentation and course of Crohn's disease (CD) is highly variable. We sought to better understand the cellular and molecular mechanisms that guide this heterogeneity, and characterise the cellular processes associated with disease phenotypes. DESIGN: We examined both gene expression and gene regulation (chromatin accessibility) in non-inflamed colon tissue from a cohort of adult patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27742763
DOI: 10.1136/gutjnl-2016-312518
PMCID: PMC5426990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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