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Article

11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.

Endocrine reviews - 1 Aug 2013

Gathercole Laura L, Lavery Gareth G, Morgan Stuart A, Cooper Mark S, Sinclair Alexandra J, Tomlinson Jeremy W, Stewart Paul M

Abstract excerpt

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts the inactive glucocorticoid cortisone and its active form cortisol. It is widely expressed and, although bidirectional, in vivo it functions predominantly as an oxoreductase, generating active glucocorticoid. This allows glucocorticoid receptor activation to be regulated at a prereceptor level in a tissue-specific manner. In this review, we will...

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PMID: 23612224
DOI: 10.1210/er.2012-1050

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