Article
Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.
Endocrinology - 1 Jul 2012
Lavery Gareth G, Zielinska Agnieszka E, Gathercole Laura L, Hughes Beverly, Semjonous Nina, Guest Phillip, Saqib Khalid, Sherlock Mark, Reynolds Gary, Morgan Stuart A, Tomlinson Jeremy W, Walker Elizabeth A, Rabbitt Elizabeth H, Stewart Paul M
Abstract excerpt
Glucocorticoids (GC) are implicated in the development of metabolic syndrome, and patients with GC excess share many clinical features, such as central obesity and glucose intolerance. In patients with obesity or type 2 diabetes, systemic GC concentrations seem to be invariably normal. Tissue GC concentrations determined by the hypothalamic-pituitary-adrenal (HPA) axis and local cortisol (corticosterone in mice)...
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