Article
An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess.
Endocrinology - 1 Mar 2014
Bentley Liz, Esapa Christopher T, Nesbit M Andrew, Head Rosie A, Evans Holly, Lath Darren, Scudamore Cheryl L, Hough Tertius A, Podrini Christine, Hannan Fadil M, Fraser William D, Croucher Peter I, Brown Matthew A, Brown Steve D M, Cox Roger D, Thakker Rajesh V
Abstract excerpt
Cushing's syndrome, which is characterized by excessive circulating glucocorticoid concentrations, may be due to ACTH-dependent or -independent causes that include anterior pituitary and adrenal cortical tumors, respectively. ACTH secretion is stimulated by CRH, and we report a mouse model for Cushing's syndrome due to an N-ethyl-N-nitrosourea (ENU) induced Crh mutation at -120 bp of the promoter region, which...
Topics
- Animals
- Body Composition
- Bone and Bones
- Calcium
- Cell Line
- Chromosome Mapping
- Corticosterone
- Corticotropin-Releasing Hormone
- Cushing Syndrome