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Article

Oral Corticosterone Administration Reduces Insulitis but Promotes Insulin Resistance and Hyperglycemia in Male Nonobese Diabetic Mice.

The American journal of pathology - 1 Mar 2017

Burke Susan J, Batdorf Heidi M, Eder Adrianna E, Karlstad Michael D, Burk David H, Noland Robert C, Floyd Z Elizabeth, Collier J Jason

Abstract excerpt

Steroid-induced diabetes is the most common form of drug-induced hyperglycemia. Therefore, metabolic and immunological alterations associated with chronic oral corticosterone were investigated using male nonobese diabetic mice. Three weeks after corticosterone delivery, there was reduced sensitivity to insulin action measured by insulin tolerance test. Body composition measurements revealed increased fat mass and...

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Identifiers

PMID: 28061324
DOI: 10.1016/j.ajpath.2016.11.009
PMCID: PMC5389359

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