Article

Physiological and behavioural characterisation of a novel steroid sulfatase-deficient mouse

2026-03-26

Abstract excerpt

<h4>Background</h4> Steroid sulfatase (STS) cleaves sulfate groups from steroid hormones. In humans, STS deficiency is associated with X-linked ichthyosis (a dermatological disorder), neurodevelopmental/mood conditions, and cardiac arrhythmias. Until recently, no single-gene ‘knockout’ mammalian model existed to investigate these associations; previous work in such a model has been limited to skin phenotypes. <h4...

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Literature Corpus work: c592d576-11af-599b-9644-2b9da19fe8dc
DOI: 10.64898/2026.03.24.713857

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