Article

TCRi: Information theoretic metrics for single cell RNA and TCR sequencing in cancer

2022-10-04

Abstract excerpt

Single-cell T cell repertoire sequencing can pair both T cell receptor (TCR) and gene expression sequence data, providing an enriched view of T cell behavior. This powerful tool can identify and characterize specific clonotypes and phenotypes as well as track their changes in response to therapy, such as immune checkpoint blockade (ICB). We present a novel information theoretic framework called TCRi for characteri...

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Literature Corpus work: 872ee55c-1b5d-5203-b9d8-5c6ee1676229
DOI: 10.1101/2022.10.01.510457

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