Article

Single-cell profiling of tumor-reactive CD4 <sup>+</sup> T-cells reveals unexpected transcriptomic diversity

2019-02-08

Abstract excerpt

Most current tumor immunotherapy strategies leverage cytotoxic CD8 + T cells. Despite evidence for clinical potential of CD4 + tumor-infiltrating lymphocytes (TILs), their functional diversity has limited our ability to harness their activity. To address this issue, we have used single-cell mRNA sequencing to analyze the response of CD4 + T cells specific for a defined recombinant tumor antigen, both in the tum...

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Literature Corpus work: c0b79b57-f4a9-5d34-8ddb-6cab6ed14c08
DOI: 10.1101/543199

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