Article
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment.
Cell - 23 Aug 2018
Azizi Elham, Carr Ambrose J, Plitas George, Cornish Andrew E, Konopacki Catherine, Prabhakaran Sandhya, Nainys Juozas, Wu Kenmin, Kiseliovas Vaidotas, Setty Manu, Choi Kristy, Fromme Rachel M, Dao Phuong, McKenney Peter T, Wasti Ruby C, Kadaveru Krishna, Mazutis Linas, Rudensky Alexander Y, Pe'er Dana
Abstract excerpt
Knowledge of immune cell phenotypes in the tumor microenvironment is essential for understanding mechanisms of cancer progression and immunotherapy response. We profiled 45,000 immune cells from eight breast carcinomas, as well as matched normal breast tissue, blood, and lymph nodes, using single-cell RNA-seq. We developed a preprocessing pipeline, SEQC, and a Bayesian clustering and normalization method,...
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