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Loss of <i>Lkb1</i> cooperates with <i>Braf</i> <sup> <i>V600E</i> </sup> and UV radiation increasing melanoma multiplicity and neural-like dedifferentiation

2024-03-29

Abstract excerpt

<h4>ABSTRACT</h4> The mechanisms cooperating with BRAF V600E oncogene in addition to ultraviolet (UV) radiation in melanoma development are of great interest. Analysis of human melanoma tumors (TCGA) indicates that 50% or more of the samples express no or low amounts of LKB1 protein. Here, we report that the concomitant neonatal Braf V600E activation and Lkb1 tumor suppressor ablation in melanocytes led to ful...

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Literature Corpus work
870c6edd-1c3b-594a-bcd6-0ddacb37a900
DOI
10.1101/2024.03.29.587140
Open publication

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Loss of <i>Lkb1</i> cooperates with <i>Braf</i> <sup> <i>V600E</i> </sup> and UV radiation increasing melanoma multiplicity and neural-like dedifferentiationDOI 10.1101/2024.03.29.587140
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