Article
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity.
Nature communications - 26 Nov 2020
Zhang Lizhou, Jackson Cody B, Mou Huihui, Ojha Amrita, Peng Haiyong, Quinlan Brian D, Rangarajan Erumbi S, Pan Andi, Vanderheiden Abigail, Suthar Mehul S, Li Wenhui, Izard Tina, Rader Christoph, Farzan Michael, Choe Hyeryun
Abstract excerpt
SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally. We therefore compare the properties of the mutated S protein (SG614) with the original (SD614). We report here pseudoviruses carrying SG614 enter ACE2-expressing cells more efficiently than those with SD614. This increased entry correlates with less S1-domain shedding and higher S-protein incorporation into the virion. Similar...
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