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Article

Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.

American journal of physiology. Gastrointestinal and liver physiology - 1 Aug 2016

Pierre Joseph F, Martinez Kristina B, Ye Honggang, Nadimpalli Anuradha, Morton Timothy C, Yang Jinghui, Wang Qiang, Patno Noelle, Chang Eugene B, Yin Deng Ping

Abstract excerpt

The metabolic benefits induced by gastric bypass, currently the most effective treatment for morbid obesity, are associated with bile acid (BA) delivery to the distal intestine. However, mechanistic insights into BA signaling in the mediation of metabolic benefits remain an area of study. The bile diversion () mouse model, in which the gallbladder is anastomosed to the distal jejunum, was used to test the...

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Identifiers

PMID: 27340128
DOI: 10.1152/ajpgi.00202.2016
PMCID: PMC5007288

Genes

PGC
PRDM16
UCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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