Article

A20 is an immune tolerance factor that can determine islet transplant outcomes

2019-09-16

Abstract excerpt

Islet transplantation can restore lost glycemic control in type 1 diabetes subjects, but is restricted in its clinical application by limiting supplies of islets and the need for heavy immune suppression to prevent rejection. TNFAIP3 , encoding the ubiquitin editing enzyme A20, regulates the activation of immune cells by raising NF-κB signalling thresholds. Here we show that increasing A20 expression in allogenei...

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Literature Corpus work: 86a78189-72df-5677-b75d-dcbd5bae0198
DOI: 10.1101/770834

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