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Article

Inflammation-Mediated Regulation of MicroRNA Expression in Transplanted Pancreatic Islets

1 Jan 2012

Abstract excerpt

Nonspecific inflammation in the transplant microenvironment results in β-cell dysfunction and death influencing negatively graft outcome. MicroRNA (miRNA) expression and gene target regulation in transplanted islets are not yet well characterized. We evaluated the impact of inflammation on miRNA expression in transplanted rat islets. Islets exposed in vitro to proinflammatory cytokines and explanted syngeneic...

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PMID: 22655170
DOI: 10.1155/2012/723614

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