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Article

Genetic Engineering of a Suboptimal Islet Graft with A20 Preserves β Cell Mass and Function

1 Jun 2003

Abstract excerpt

Transplantation of an excessive number of islets of Langerhans (two to four pancreata per recipient) into patients with type I diabetes is required to restore euglycemia. Hypoxia, nutrient deprivation, local inflammation, and the beta cell inflammatory response (up-regulation of NF-kappaB-dependent genes such as inos) result in beta cell destruction in the early post-transplantation period. Genetic engineering of...

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PMID: 12794157
DOI: 10.4049/jimmunol.170.12.6250

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