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Full-length transcript characterization of <i>SF3B1</i> mutation in chronic lymphocytic leukemia reveals downregulation of retained introns

2018-09-06

Abstract excerpt

SF3B1 is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL) and is associated with poor patient prognosis. While alternative splicing patterns caused by mutations in SF3B1 have been identified with short-read RNA sequencing, a critical barrier in understanding the functional consequences of these splicing changes is that we lack the full transcript context in which these changes are oc...

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Literature Corpus work
2db83c17-d1a5-5cd6-89e6-05d182bda5d8
DOI
10.1101/410183
Open publication

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Full-length transcript characterization of <i>SF3B1</i> mutation in chronic lymphocytic leukemia reveals downregulation of retained intronsDOI 10.1101/410183
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