The significance of spliceosome mutations in chronic lymphocytic leukemia.

Abstract excerpt

Cellular proteins produced via alternative splicing provide neoplastic cells with survival advantage and/or promote neoplastic cell proliferation. Pre-mRNA is spliced by the spliceosome consisting of large complexes of small nuclear RNA (snRNA) and protein subunits. Spliceosome gene mutations were detected in 40-80% of patients with myelodysplastic syndrome (MDS), particularly in those with ringed sideroblasts....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Leukemia, Lymphocytic, Chronic, B-Cell
• Share to Mutation
• Share to Myelodysplastic Syndromes