Article

lncRNA CHASERR Integrates Transcriptional and Post-Transcriptional Gene Regulation

2025-12-30

Abstract excerpt

Long non-coding RNAs (lncRNAs) are critical regulators of chromatin and gene expression, yet their precise molecular mechanisms are often undefined. CHASERR exemplifies this challenge: haploinsufficiency of this locus causes a severe neurodevelopmental syndrome, positioning it as a master epigenetic regulator, but its physical interactors and modes of action remain unknown. Here, we define the CHASERR interactome...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 869a7f5f-17c9-5e30-9d74-eeb98cc7beed
DOI: 10.12688/f1000research.175457.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

lncRNA CHASERR Integrates Transcriptional and Post-Transcriptional Gene RegulationDOI 10.12688/f1000research.175457.1Read

Regulation of CHD2 expression by the <i>Chaserr</i> long noncoding RNA is essential for viabilitySemantic proximity Read

RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts.Semantic proximity Read

Extending cis-regulatory networks using chromatin-RNA interactionsSemantic proximity Read

Discovery of the TGCB microprotein translated from the lncRNA CHASERRSemantic proximity Read

<i>cis</i> -Regulatory Chromatin Contacts in Neural Cells Reveal Contributions of Genetic Variants to Complex Neurological DisordersSemantic proximity Read

Novel syndromic neurodevelopmental disorder caused by de novo deletion of<i>CHASERR</i>, a long noncoding RNASemantic proximity Read

Mammalian enhancers and GWASs act proximally and seldom skip active genesSemantic proximity Read

Global Mapping of circRNA-Target RNA Interactions Reveals P-Body-Mediated Translational RepressionSemantic proximity Read

Whole genome functional characterization of RE1 silencers using a modified massively parallel reporter assaySemantic proximity Read

Beyond the Double Helix: Unraveling the Intricacies of DNA and RNA NetworksSemantic proximity Read

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCNSemantic proximity Read

Enhancer RNA transcriptome-wide association study reveals an atlas of pan-cancer susceptibility eRNAsSemantic proximity Read