Global Mapping of circRNA-Target RNA Interactions Reveals P-Body-Mediated Translational Repression

Abstract excerpt

<h4>SUMMARY</h4> Circular RNAs (circRNAs) are primarily produced through pre-mRNA back-splicing, yet their target repertoire and functional mechanisms remain elusive. Here, we present circTargetMap, a computational framework for globally mapping circRNA targets using RNA-RNA interactomes obtained via RNA in situ conformation sequencing (RIC-seq) in the hippocampus and ten human cell lines. This approach identifie...

Topics

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• Gene Expression Regulation, Neoplastic
• HEK293 Cells
• HeLa Cells
• Nucleic Acid Conformation
• Protein Biosynthesis
• Receptor, Fibroblast Growth Factor, Type 1
• RNA, Circular
• Structure-Activity Relationship

Identifiers and source

Literature Corpus work

1d516a6b-9537-57f2-8cf6-14f1973decfa

DOI

10.1101/2025.11.16.688748