Article

Discovery of the TGCB microprotein translated from the lncRNA CHASERR

2025-12-07

Abstract excerpt

Long noncoding RNAs (lncRNAs) are key regulators of gene expression, and an increasing number have been found to contain small open reading frames (smORFs) that can be translated into functional microproteins. CHASERR is a conserved cis-regulatory lncRNA positioned upstream of CHD2 , where it fine-tunes CHD2 dosage. Deletions spanning the CHASERR gene were recently identified in children with a syndromic, earl...

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Literature Corpus work: 7deebf88-835f-5da2-af9f-c227dbf83f05
DOI: 10.64898/2025.12.04.692433

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