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Article

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

4 Jul 2023

Abstract excerpt

Circular RNAs (circRNAs) are a regulatory RNA class. While cancer-driving functions have been identified for single circRNAs, how they modulate gene expression in cancer is not well understood. We investigate circRNA expression in the pediatric malignancy, neuroblastoma, through deep whole-transcriptome sequencing in 104 primary neuroblastomas covering all risk groups. We demonstrate that MYCN amplification,...

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PMID: 37402719
DOI: 10.1038/s41467-023-38747-4

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