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Article

Restoring Cancer Genomes: Functional Mutation Correction as a Platform for Precision Oncology.

Human gene therapy - 1 Aug 2026

Wang Pascal, Sayed Shady, Buchholz Frank

Abstract excerpt

Cancer genome sequencing has uncovered an extensive landscape of somatic mutations. However, determining which of these alterations are biologically consequential and therapeutically actionable remains a central challenge in oncology. CRISPR-based genome editing now enables precise correction of oncogenic mutations within their endogenous genomic context. Recent work demonstrates that repairing cancer hotspot...

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PMID: 42504876
DOI: 10.1177/10430342261468973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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