Article

Single-nucleus transcriptomic analysis of pediatric pancreas reveals cellular heterogeneity and early neoplasia signatures during chronic pancreatitis

2026-07-04

Abstract excerpt

<h4>Background</h4> Pediatric chronic pancreatitis (CP) carries an elevated lifetime risk of pancreatic ductal adenocarcinoma (PDAC), yet the cellular and molecular mechanisms driving disease progression and early neoplastic transformation remain undefined. <h4>Methods</h4> We performed single-nucleus RNA sequencing (snRNA-seq) on pancreatic tissue from 15 pediatric CP individuals and 6 healthy controls (HC). Fi...

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Literature Corpus work: 868d42b4-e242-5e2e-b287-a17e2ace881f
DOI: 10.64898/2026.07.01.26357053

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