Article
Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree.
eLife - 19 May 2021
Hendley Audrey M, Rao Arjun A, Leonhardt Laura, Ashe Sudipta, Smith Jennifer A, Giacometti Simone, Peng Xianlu L, Jiang Honglin, Berrios David I, Pawlak Mathias, Li Lucia Y, Lee Jonghyun, Collisson Eric A, Anderson Mark S, Fragiadakis Gabriela K, Yeh Jen Jen, Ye Chun Jimmie, Kim Grace E, Weaver Valerie M, Hebrok Matthias
Abstract excerpt
To study disease development, an inventory of an organ's cell types and understanding of physiologic function is paramount. Here, we performed single-cell RNA-sequencing to examine heterogeneity of murine pancreatic duct cells, pancreatobiliary cells, and intrapancreatic bile duct cells. We describe an epithelial-mesenchymal transitory axis in our three pancreatic duct subpopulations and identify osteopontin as a...
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