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Article

Single-Nucleus and In Situ RNA–Sequencing Reveal Cell Topographies in the Human Pancreas

16 Nov 2020

Abstract excerpt

Background & Aims Molecular evidence of cellular heterogeneity in the human exocrine pancreas has not been yet established because of the local concentration and cascade of hydrolytic enzymes that can rapidly degrade cells and RNA upon pancreatic resection. We sought to better understand the heterogeneity and cellular composition of the pancreas in neonates and adults in healthy and diseased conditions using...

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PMID: 33212097
DOI: 10.1053/j.gastro.2020.11.010

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