Article

Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions

2023-01-15

Abstract excerpt

The adult healthy human pancreas has been poorly studied given lack of indication to obtain tissue from the pancreas in the absence of disease and rapid postmortem degradation. We obtained pancreata from brain dead donors thus avoiding any warm ischemia time. The 30 donors were diverse in age and race and had no known pancreas disease. Histopathological analysis of the samples revealed PanIN lesions in most indivi...

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Literature Corpus work: 18d7e65f-e41d-59ba-9fe3-1dac82142bfd
DOI: 10.1101/2023.01.13.523300

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