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Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15

6 Aug 2019

Abstract excerpt

The risk of colorectal cancer (CRC) varies between people, and the cellular mechanisms mediating the differences in risk are largely unknown. Senescence has been implicated as a causative cellular mechanism for many diseases, including cancer, and may affect the risk for CRC. Senescent fibroblasts that accumulate in tissues secondary to aging and oxidative stress have been shown to promote cancer formation via a...

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PMID: 31389184
DOI: 10.1111/acel.13013

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