Article

Excessive ERK-dependent synaptic clustering drives enhanced motor learning in the MECP2 duplication syndrome mouse model of autism

2017-01-16

Abstract excerpt

Autism-associated genetic mutations may produce altered learning abilities by perturbing the balance between stability and plasticity of synaptic connections in the brain. Here we report an increase in the stabilization of dendritic spines formed during repetitive motor learning in the mouse model of MECP2 -duplication syndrome, a high-penetrance form of syndromic autism. This increased stabilization is mediated...

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Literature Corpus work: 8687f63f-7932-5eca-a613-d8ee187ad50a
DOI: 10.1101/100875

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