Article

MeCP2 is Necessary in Cerebellar Purkinje Cells for Precise Network Dynamics During Associative Motor Learning

2026-05-26

Abstract excerpt

Loss-of-function variants of MECP2 cause Rett syndrome; however, their impact on cerebellar computations for learning remains poorly understood. Here, we show that Mecp2 deletion specifically in Purkinje cells does not broadly disrupt cerebellar-dependent behaviors but selectively compromises those that require precise timing, coordination, and associative updating in the cerebellar cortex. Mecp2 loss altered t...

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Literature Corpus work: 61aba7bf-49ae-5f9c-beac-9ffcbb8883ee
DOI: 10.64898/2026.05.25.727684

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