Article

Increased axonal bouton stability during learning in the mouse model of MECP2 duplication syndrome

2017-09-08

Abstract excerpt

<h4>ABSTRACT</h4> MECP2 -duplication syndrome is an X-linked form of syndromic autism caused by genomic duplication of the region encoding Methyl-CpG-binding protein 2. Mice overexpressing MECP2 demonstrate altered patterns of learning and memory, including enhanced motor learning. Previous work associated this enhanced motor learning to abnormally increased stability of dendritic spine clusters formed in the ap...

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Literature Corpus work: acc5e7c8-a83f-55cd-be96-85b273eef67c
DOI: 10.1101/186239

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