Article

A Quantitative Evaluation of Topological Motifs and Their Coupling in Gene Circuit State Distributions

2022-07-20

Abstract excerpt

One of the major challenges in biology is to understand how gene interactions collaborate to determine overall functions of biological systems. Here, we present a new computational framework that enables systematic, high-throughput, and quantitative evaluation of how small transcriptional regulatory circuit motifs, and their coupling, contribute to functions of a dynamical biological system. We illustrate how this...

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Literature Corpus work: 5ef2dc3b-9d48-533e-a84a-c03a1c64b039
DOI: 10.1101/2022.07.19.500691

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