Article

Endosome-escaping engineered LNP-miR146a with in vivo biodistribution to mitigate inflammation and foreign body giant cell formation

2026-02-14

Abstract excerpt

Nanomaterial-enabled delivery systems have transformed therapeutic strategies for treating inflammatory and degenerative diseases by enabling targeted delivery of small molecules and nucleic acids. However, the clinical translation of microRNA (miR) therapeutics remains limited by instability, enzymatic degradation, and inefficient intracellular delivery in biological environments. Here, we present the design and...

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Literature Corpus work: 865e110a-748b-55ce-8596-c715a48f8867
DOI: 10.64898/2026.02.13.705811

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Endosome-escaping engineered LNP-miR146a with in vivo biodistribution to mitigate inflammation and foreign body giant cell formationDOI 10.64898/2026.02.13.705811Read

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