Back to search

Article

Advanced RNA Therapeutics: "Molecular Scalpels" for Cartilage Microenvironment Remodeling

2026-08-04

Abstract excerpt

Osteoarthritis (OA) is a debilitating degenerative joint disease urgently requiring disease-modifying therapies. Although multimodal RNA therapeutics (e.g., siRNA, miRNA, and mRNA) exhibit immense potential in reprogramming the complex OA pathological network, their clinical translation remains severely impeded by the hostile intra-articular microenvironment and rapid nucleolytic degradation. This review comprehen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7c367c8d-fc15-56b5-9881-68b9986a2908
DOI
10.20944/preprints202608.0120.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Advanced RNA Therapeutics: "Molecular Scalpels" for Cartilage Microenvironment RemodelingDOI 10.20944/preprints202608.0120.v1
A Combinatorial mRNA Therapy for Treating Rheumatoid Arthritis and Osteoarthritis by Inhibiting Inflammation and Promoting Cartilage RegenerationSemantic proximity
Advances in RNA Therapeutics: Classes, Innovations and Clinical ApplicationsSemantic proximity
Oral Spatiotemporal Nanoassembly for Sequential Genetic Reprogramming from Gut to Periphery OrganSemantic proximity
Unlocking the potential of exosomes: a breakthrough in the theranosis of degenerative orthopaedic diseasesSemantic proximity
Biomaterial Strategies in Osteoarthritis: New Insights Bridging Aging Phenotypes and Hypoxic Microenvironment Pathology.Semantic proximity
Enhancing Cartilage Repair: Surgical Approaches, Orthobiologics, and the Promise of ExosomesSemantic proximity
Lipid Nanoparticle Delivery Systems to Enable mRNA-Based TherapeuticsSemantic proximity
A Single Lipid Nanoparticle Formulation Enables Delivery of Diverse RNA Therapeutics to Human Muscle Models of Duchenne Muscular DystrophySemantic proximity
Nanomaterials-assisted gene editing and synthetic biology for optimizing the treatment of pulmonary diseasesSemantic proximity
RNA nanotherapeutics for hepatocellular carcinoma treatmentSemantic proximity
Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing <i>in vivo</i>Semantic proximity
Transfection Technologies for Next-Generation TherapiesSemantic proximity
Select a neighboring publication to make it the new centre.