Article
siAkt2-Loaded Nanoparticles Reprogramming Macrophages to M2 Phenotype for Effective Bone Defect Repair.
Advanced materials (Deerfield Beach, Fla.) - 1 Jan 2026
Cui Shengjie, Wu Xiaowei, Yu Xiaotong, Huang Yiqian, Zhang Daixing, Chen Haotian, Heng Boon Chin, Cai Qing, Wang Yixiang, Gu Yan, Deng Xuliang
Abstract excerpt
Targeted siRNA delivery has been widely used to regulate cell function. However, the rapid degradation of siRNA within macrophages upon delivery severely limits its utility for regulating macrophage function. Here, a novel technique is developed to compact large amounts of siAkt2 strands into delivery nanoparticles, to achieve massive and sustained intracellular release of siAkt2 that overwhelms the degradation...
Read the complete abstract on PubMedTopics
- Animals
- Mice
- Nanoparticles
- Macrophages
- RAW 264.7 Cells
- RNA, Small Interfering