Article

Amyloid-β seeding effects are dependent on the presence of knock-in genes in the App <sup>NL-G-F</sup> mice

2022-05-29

Abstract excerpt

Alzheimer’s disease (AD) is characterized by the prion-like propagation of amyloid-β (Aβ). However, the role of Aβ in cognitive impairment is still unclear. To determine the causal role of Aβ in AD, we intracerebrally seeded the entorhinal cortex of two-month-old App NL-G-F mouse model with an Aβ peptide derived from patients who died from rapidly progressing AD. When the mice were three and six months of age, or...

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Identifiers and source

Literature Corpus work: 86490882-6274-57df-b96d-6e42a585b6ee
DOI: 10.1101/2022.05.28.492382

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