Article
Human mitochondrial tRNAs: biogenesis, function, structural aspects, and diseases.
Annual review of genetics - 1 Jan 2011
Suzuki Tsutomu, Nagao Asuteka, Suzuki Takeo
Abstract excerpt
Mitochondria are eukaryotic organelles that generate most of the energy in the cell by oxidative phosphorylation (OXPHOS). Each mitochondrion contains multiple copies of a closed circular double-stranded DNA genome (mtDNA). Human (mammalian) mtDNA encodes 13 essential subunits of the inner membrane complex responsible for OXPHOS. These mRNAs are translated by the mitochondrial protein synthesis machinery, which...
Topics
- Amino Acyl-tRNA Synthetases
- Aminoacylation
- Animals
- Humans
- MELAS Syndrome
- Mammals
- Mitochondria
- Mitochondrial Diseases
- Mutation
- Oxidative Phosphorylation
- Protein Conformation
- RNA
- RNA Processing, Post-Transcriptional
- RNA, Mitochondrial
- RNA, Transfer
- Thiouridine
- Transcription, Genetic
- Uridine