Novel tRNA-like transcripts from the NEAT1-MALAT1 genomic region critically influence human innate immunity and macrophage functions

Abstract excerpt

<title>Abstract</title> <p>The evolutionary conserved NEAT1-MALAT1 gene cluster generates large noncoding transcripts remaining nuclear, while tRNA-like transcripts (mascRNA, menRNA) enzymatically generated from these precursors translocate to the cytosol. NEAT1-/- and MALAT1-/- mice display massive atherosclerosis and vascular inflammation. Here, we identify the tRNA-like molecules as critical components of inna...

Topics

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• Cell Nucleus
• Chromatin
• Gene Expression Regulation, Developmental
• In Situ Hybridization, Fluorescence
• RNA Editing
• RNA, Long Noncoding
• RNA Precursors
• RNA Splicing

Identifiers and source

Literature Corpus work

72a65344-d6db-5eda-936e-65ff87ac09b8

DOI

10.21203/rs.3.rs-1540419/v2