Article

Immunological profiles in Lynch syndrome colorectal cancers are not specific to mismatch repair gene defects

2024-08-28

Abstract excerpt

<h4>Background and aims</h4> Colorectal carcinomas (CRCs) in patients with Lynch syndrome (LS) exhibit heightened immunogenicity due to mismatch repair deficiency (MMR-d), often resulting in favorable responses to T cell immune checkpoint therapies. Recent studies indicate that the phenotype and genotype of LS-associated CRCs vary depending on the specific MMR gene mutated. Here, we investigated whether the immune...

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Literature Corpus work: 863fd34b-113c-5543-ae35-f4d4bdd26828
DOI: 10.1101/2024.08.27.24311855

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