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Mismatch Repair Proficient Colorectal Adenocarcinoma in Two Patients With Lynch Syndrome

11 Dec 2024

Abstract excerpt

Screening for Lynch syndrome (LS) is essential in colorectal carcinoma (CRC) diagnosis. The hallmark of CRC in LS is mismatch repair (MMR) deficiency, a vital biomarkers assessed by microsatellite instability (MSI) analysis and/or immunohistochemistry (IHC) staining of the MMR proteins in the tumor, that also predict response to immune checkpoint inhibitors. We report two LS patients who developed MMR proficient...

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PMID: 39660603
DOI: 10.1111/cge.14670

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