Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lynch syndrome-associated epithelial ovarian cancer and its immunological profile.

Gynecologic oncology - 1 Sept 2021

Rasmussen Maria, Lim Kevin, Rambech Eva, Andersen Mads Hald, Svane Inge Marie, Andersen Ove, Jensen Lars Henrik, Nilbert Mef, Therkildsen Christina

Abstract excerpt

INTRODUCTION: Lynch syndrome is a multi-tumor syndrome characterized by mismatch repair deficiency (MMR-d), microsatellite instability (MSI), and increased tumor-infiltrating lymphocytes (TILs) making these tumors candidates for treatment with immune checkpoint inhibitors. However, response may depend on tumor-induced immune evasion mechanisms, e.g. loss of Beta-2-Microglobulin (B2M) or upregulation of programmed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B7-H1 Antigen
Share to beta 2-Microglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Ovarian Epithelial

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to Immunotherapy

Share to Lymphocytes, Tumor-Infiltrating

Share to Microsatellite Instability

Share to Registries

Source

Identifiers

PMID: 34275654
DOI: 10.1016/j.ygyno.2021.07.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lynch syndrome-associated epithelial ovarian cancer and its immunological profile.PMID 34275654Read ↗

Immunoprofiles of colorectal cancer from Lynch syndromeSemantic proximity Read ↗

Immunological profiles in Lynch syndrome colorectal cancers are not specific to mismatch repair gene defectsSemantic proximity Read ↗

Immune escape and resistance to immunotherapy in mismatch repair deficient tumorsSemantic proximity Read ↗

Lynch syndrome - cancer pathways, heterogeneity and immune escape.Semantic proximity Read ↗

Immunotherapy and patients treated for cancer with microsatellite instability.Semantic proximity Read ↗

Immunology of Lynch SyndromeSemantic proximity Read ↗

Distinct Immunological Landscapes Characterize Inherited and Sporadic Mismatch Repair Deficient Endometrial CancerSemantic proximity Read ↗

Typing the tumor immune signatures in patients of Lynch syndrome facilitates predicting the responsiveness of immune checkpoint inhibitionSemantic proximity Read ↗

Immune checkpoint inhibitors for the treatment of MSI-H/MMR-D colorectal cancer and a perspective on resistance mechanismsSemantic proximity Read ↗

Immunotherapy with immune checkpoint inhibitors in colorectal cancer: what is the future beyond deficient mismatch-repair tumours?Semantic proximity Read ↗

Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome.Semantic proximity Read ↗

Immunoediting on the Brink: Dynamic Relationship Between Tumor Genotype and Microenvironment as Determinant of Immunotherapy Effectiveness in an informative case report of Lynch SyndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.