Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunoprofiles of colorectal cancer from Lynch syndrome

26 Sept 2018

Abstract excerpt

Colorectal cancers associated with Lynch syndrome are characterized by defective mismatch repair, microsatellite instability, high mutation rates, and a highly immunogenic environment. These features define a subset of cancer with a favorable prognosis and high likelihood to respond to treatment with anti-programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) drugs. With the aim to define immune-evasive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Colorectal Cancer Treatments and Studies
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30546958
DOI: 10.1080/2162402x.2018.1515612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunoprofiles of colorectal cancer from Lynch syndromePMID 30546958Read ↗

Lynch syndrome-associated epithelial ovarian cancer and its immunological profile.Semantic proximity Read ↗

Immunological profiles in Lynch syndrome colorectal cancers are not specific to mismatch repair gene defectsSemantic proximity Read ↗

Lynch syndrome - cancer pathways, heterogeneity and immune escape.Semantic proximity Read ↗

Immunology of Lynch SyndromeSemantic proximity Read ↗

Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome.Semantic proximity Read ↗

Oncological characteristics, treatments and prognostic outcomes in MMR-deficient colorectal cancerSemantic proximity Read ↗

The distinct clinical trajectory, metastatic sites, and immunobiology of microsatellite-instability-high cancersSemantic proximity Read ↗

Challenges and Therapeutic Opportunities in the dMMR/MSI-H Colorectal Cancer LandscapeSemantic proximity Read ↗

Mutational signature profiling classifies subtypes of clinically different mismatch repair deficient tumors with a differential immunogenic response potentialSemantic proximity Read ↗

The clinical implications of immunogenomics in colorectal cancer: A path for precision medicineSemantic proximity Read ↗

Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal CancerSemantic proximity Read ↗

Pembrolizumab alters the tumor immune landscape in a patient with dMMR glioblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.