Differential Responses to Immune Checkpoint Inhibitors are Governed by Diverse Mismatch Repair Gene Alterations.

doi:10.1158/1078-0432.CCR-23-3004

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Article

Differential Responses to Immune Checkpoint Inhibitors are Governed by Diverse Mismatch Repair Gene Alterations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2024

Khushman Moh'd M, Toboni Michael D, Xiu Joanne, Manne Upender, Farrell Alex, Lou Emil, Shields Anthony F, Philip Philip A, Salem Mohamed E, Abraham Jim, Spetzler David, Marshall John, Jayachandran Priya, Hall Michael J, Lenz Heinz-Josef, Sahin Ibrahim Halil, Seeber Andreas, Powell Mathew A

Abstract excerpt

PURPOSE: The response to immune checkpoint inhibitors (ICI) in deficient mismatch repair (dMMR) colorectal cancer and endometrial cancer is variable. Here, we explored the differential response to ICIs according to different mismatch repair alterations. EXPERIMENTAL DESIGN: Colorectal cancer (N = 13,701) and endometrial cancer (N = 3,315) specimens were tested at Caris Life Sciences. Median overall survival (mOS)...

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PMID: 38350001
DOI: 10.1158/1078-0432.CCR-23-3004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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