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Challenges and Therapeutic Opportunities in the dMMR/MSI-H Colorectal Cancer Landscape

6 Feb 2023

Abstract excerpt

About 5 to 15% of all colorectal cancers harbor mismatch repair deficient/microsatellite instability-high status (dMMR/MSI-H) that associates with high tumor mutation burden and increased immunogenicity. As a result, and in contrast to other colorectal cancer phenotypes, a significant subset of dMMR/MSI-H cancer patients strongly benefit from immunotherapy. Yet, a large proportion of these tumors remain...

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PMID: 36831367
DOI: 10.3390/cancers15041022

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