Article

Polymorphisms in immunoglobulin heavy chain variable genes and their upstream regions

2020-01-28

Abstract excerpt

<h4>ABSTRACT</h4> Germline variations in immunoglobulin genes influence the repertoire of B cell receptors and antibodies, and such polymorphisms may impact disease susceptibility. However, the knowledge of the genomic variation of the immunoglobulin loci is scarce. Here, we report 25 novel germline IGHV alleles as inferred from rearranged naïve B cell cDNA repertoires of 98 individuals. Thirteen novel alleles w...

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Literature Corpus work: 86276daa-3c92-5605-bddb-92f8e7afd36f
DOI: 10.1101/2020.01.27.921197

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